Podcast Editor, Tracy Carlson, interviews author Matt Jacobsen to discuss the article, "Utilizing Whole Slide Images for the Primary Evaluation and Peer Review of a GLP-Compliant Rodent Toxicology Study" which can currently be found in Vol 49, Issue 6, 2021 of Toxicologic Pathology.

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Podcast Editor, Charles Wood, interviews author Justin Vidal on the article, "Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies" which can currently be found in Vol 49, Issue 5, 2021 of Toxicologic Pathology.

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Podcast Editor, Liz McInnes, interviews authors Hannah Pischon and Valeria Bertani to discuss the article, "Artificial Intelligence in Toxicologic Pathology: Quantitative Evaluation of Compound-Induced Hepatocellular Hypertrophy in Rats" which can currently be found in Vol 49, Issue 4, 2021 of Toxicologic Pathology.

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Podcast Host, Tracy Carlson, interviews author Steven Sorden to discuss the article, "Introduction to Special Issue on Ocular Pathology and Drug Development" which can currently be found in Vol 49, Issue 3, 2021 of Toxicologic Pathology.

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Podcast Host, Charles Wood, interviews author Peter Hall to discuss the article, "BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics" which can currently be found in Vol 49, Issue 2, 2021 of Toxicologic Pathology.

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Podcast Editor, Liz McInnes, interviews authors Emily Meseck, Jochen Woicke, and Jessica Caverly Rae to discuss the article, "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog" which can currently be found in Vol 49, Issue 1, 2021 of Toxicologic Pathology.

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Podcast Editor, Charles Wood, interviews author Jack Harkema to discuss the article, "Pathogenesis and Persistence of Increased Epithelial Mucosubstances in the Nasal Airways of Rats and Mice Episodically Exposed to Ethylene" which can currently be found in Vol 48, Issue 7, 2020 of Toxicologic Pathology.

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Podcast Editor, Liz McInnes, interviews authors Renee R. Hukkanen, Armando Irizarry, James D. Fikes and Kenneth A. Schafer to discuss the article, "Opinion on Performing Pathology Peer-Review During the Global Pandemic: Challenges and Opportunities" which can currently be found in Vol 48, Issue 8, 2020 of Toxicologic Pathology.

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Associate Editor, Kevin Keane, interviews Bindu Bennet on her article, "Review of Current Vaccine Development Strategies to Prevent Coronavirus Disease 2019 (COVID-19)". The article can be found in Vol 48, Issue 7, 2020.

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Podcast Editor, Charles Wood, interviews author Zaher Radi and Thomas Wynn to discuss the article, "Opinion on Immune Tolerance Therapeutic Development" which can currently be found in Vol. 48, Issue 6 of Toxicologic Pathology.

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Podcast Editor, Tracy Carlson, interviews author Kristen Hobbie to discuss the article, "Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats" which can currently be found in Vol. 48, Issue 5 of Toxicologic Pathology.

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Podcast Editor, Liz McInnes, interviews author Brad Bolon to discuss the article, "The Exposome in Toxicologic Pathology" which can currently be found in Volume 48, Issue 6 of Toxicologic Pathology.

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Podcast Editor, Tracy Carlson, interviews author John Foster to discuss the article, "The Cumulative Risk Assessment of Hepatotoxic Chemicals: A Hepatic Histopathology Perspective" which can be found in Volume 48, Issue 3 of Toxicologic Pathology.

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Podcast Editor, Tracy Carlson, interviews authors Brad Bolon, Deepa Rao and Ingrid Pardo to discuss the Toxicologic Pathology Special Issue entitled: "Toxicologic Neuropathology of the Peripheral Nervous System: A Special Compendium of Past, Present, and Future Developments in a Neglected Field" which can be found in Volume 48, Issue 1.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Oliver Turner to discuss the article "Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathology" featured in the Vol 48, Issue 2, 2020 of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Renee Hukkanen to discuss the article "The Toxicologic Pathologist’s Role in the 3Rs" featured in the Vol 47, Issue 7, 2019 of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Cynthia Willard-Mack to discuss the article "Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System" featured in the August 2019 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Janardhan Kyathanahalli to discuss the article "Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program" featured in the July 2019 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Béatrice Gauthier to discuss the article "Opinion on Integrating Innovative Digital Pathology Tools in the Regulatory Framework" featured in the June 2019 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Matt Jacobsen to discuss their article "Opinion on Considerations for the Use of Whole Slide Images in GLP Pathology Peer Review" featured in the February 2019 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Daniel G. Rudmann to discuss their article "The Emergence of Microphysiological Systems (Organs-on-chips) as Paradigm-changing Tools for Toxicologic Pathology" featured in the January 2019 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites authors Nicholas E. Langevin, Kenneth A. Schafer, Oliver C. Turner, Brittany J. McPherson, and Robert E. Rose to discuss their article "Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies" featured in the October 2018 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Darlene Dixon to discuss her article "Preparation of Three-dimensional (3-D) Human Liver (HepaRG) Cultures for Histochemical and Immunohistochemical Staining and Light Microscopic Evaluation" featured in the August 2018 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Sean P. Troth to discuss his article "Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists" featured in the July 2018 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites author Wendy G. Halpern to discuss her article "Use of Severity Grades to Characterize Histopathologic Changes" featured in the April 2018 issue of Toxicologic Pathology.

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In this podcast, Editorial Board member Elizabeth McInnes invites authors Evan Janovitz and Magnus Söderberg to discuss their article "Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats" featured in the February 2018 issue of Toxicologic Pathology.

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In this podcast, Associate Editor Denise Bounous and author Michelle C. Cora discuss her article "A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice" featured in the July 2017 issue of Toxicologic Pathology. 

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In this podcast, Associate Editor Jerrold Ward and author Cynthia Besch-Williford discuss her article "A Naturally Transmitted Epitheliotropic Polyomavirus Pathogenic in Immunodeficient Rats: Characterization, Transmission, and Preliminary Epidemiologic Studies" featured in the July 2017 issue of Toxicologic Pathology. 

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In this podcast, Associate Editor Denise Bounous discusses the February 2017 Special Issue with guest editors Adam Aulbach, Holly Jordan, and Jacqueline Tarrant. The editors discuss Contemporary and Emerging Applications in Clinical Pathology and provide information on the articles in the issue.

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In this podcast, Dr. Sydney Mukaratirwa discusses this study which was conducted to characterize lung microscopic lesions in control beagle dogs from inhalation and oral gavage toxicity studies, to determine differences associated with the route of administration, and to discuss distinguishing features from compound-induced lung lesions. 

In this Toxicologic Pathology podcast, Stacey L. Fossey interviews author Peter Hall on his article "Femoral Head Growth Plate Dysplasia and Fracture in Juvenile Rabbits Induced by Off-target Antiangiogenic Treatment." Epiphyseal growth plate dysplasia (chondrodysplasia) might be considered as the pathognomonic feature of antiangiogenic treatment in preclinical species as it is reliably and dose-responsively induced in rodents and monkeys with vascular endothelial growth factor receptor (VEGFR) inhibitors, fibroblast growth factor (FGF) receptor inhibitors, matrix metalloproteinase inhibitors, and vascular targeting agents. The article suggests that the high prevalence of growth plate fracture in the rabbit may represent a potential additional adverse risk to those already established for children treated with antiangiogenic therapy.

This podcast with Dr. Sam Cohen and hosted by Dr. Peter Hall  concerns the publication of a STP committee chaired by Dr. Charles Wood concerning the role of increased cell proliferation in the evaluation of the mode of action of carcinogenesis, particularly for nongenotoxic chemicals.  Dr. Cohen emphasizes the importance of attention to details in assessing cell proliferation, with different approaches necessary for various tissues and circumstances.  He also emphasizes that the focus is on the number of cell replications, not necessarily the rate, and that it is the tissue stem cell population that is critical.  For nongenotoxic chemicals the mode of action always involves an increase in cell proliferation, and this can be utilized in designing a short (e.g. 90 days) study to screen for carcinogenesis in rodents.  Such a screen requires a labeling index (BrdU, Ki-67, PCNA) in addition to standard histopathology.  If positive, additional short term studies can be performed to evaluate the dose response in detail and to determine the mode of action and its relevance to humans.  Ultimately, this could replace the standard 2 year bioassay.

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This podcast with Dr. Jeff Wolf discusses the development of a career in the specialized field of fish pathology, and the use of fish in biomedical and environmental research.  As a veterinary pathologist, Dr. Wolf became involved with fish research during his graduate studies and as part of his present job with EPL.  Major uses of fish in toxicology include endocrine disruption research, toxicity screening, assessment of environmental contaminant effects, target animal safety studies (e.g., fish pharmaceuticals), and carcinogenesis research, the last of which was originally prompted by findings of endemic tumors in fish from polluted waters.  Dr. Wolf recently collaborated with 17 other fish pathologists in a Toxicologic Pathology review article that describes and illustrates some common diagnostic misinterpretations evident in the peer-reviewed fish literature, and makes recommendations for improving the quality of papers that publish fish histopathology data.  Dr. Wolf participates in numerous meetings and workshops involving fish toxicology and pathology, and is especially grateful for the opportunity to be able to teach these subjects at Aquavet II, CL Davis courses, and at other domestic and overseas venues. 

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A discussion with Drs. Nancy Everds, Nianyu Li and Katherine Sprugel from Amgen in Seattle, Washington about the article “Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody”.  This manuscript won the journal’s best paper award in 2013 and describes a study that is a cautionary tale for those investigating/testing monoclonal antibodies.

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This podcast provides further insights on mitochondrial pathology resulting from long-term treatment of patients infected with human immunodeficiency virus using cocktails of nucleoside analog reverse transcriptase inhibitors (NRTIs).  The respondent is Dr. Brendan Payne, a clinician at the Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK with an interest in diagnosis and treatment of infectious disease--and specifically human immunodeficiency virus (HIV); Dr. Payne is the senior author of a recent review article, "HIV Treatment and Associated Mitochondrial Pathology: Review of 25 Years of In Vitro, Animal, and Human Studies."  Dr. Payne's research suggests that the cumulative exposure to NRTIs is more important than the peak levels, indicating that the usual design of animal experiments (short terms with high doses, histopathology as a major endpoint) to model human responses may understate or even miss the consequences to patients who may be expected to remain on cocktails of these agents for life.  Dr. Payne describes the utility of various test modalities as potential means for detecting mitochondrial damage when such an outcome is suspected.

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A discussion with Dr. Igor Mikaelian from AbbVie Bioresearch in Worcester MA about special issue 4 that focuses on drug induced vascular injury. The discussion centers on why drug-induced vascular injury in animals is an issue, why is it important when developing new pharmaceuticals, what efforts are underway to address human risk assessment of vascular injury, and how the articles in this issue benefit the pharmaceutical and biotech industries.

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